Office of Research Infrastructure Programs (ORIP)

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Mission Statement

ORIP advances the NIH mission to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.

Interest Areas

General Topics

The Office of Research Infrastructure Programs (ORIP) advances the NIH mission by supporting infrastructure for innovation. General Topics of Interest for ORIP include: 

  • Models and related biomaterials for human diseases
  • Cutting-edge scientific instrumentation and equipment
  • Construction and modernization of shared use biomedical research or resource facilities
  • Development of biomedical models, biomaterials, and related methods and technologies under the NIH SEED funding program
  • Research training opportunities for scientists 

Highlighted Topics

Title Lead ICO Participating ICOs Posted Date Expiration Date

Funding Opportunities and Notices

Search for ORIP’s funding opportunities and notices

Additional Information by Funding Category

Administrative Supplements
In addition to our Administrative Supplements overview, consider the following ORIP-specific information.
Administrative Supplement Interest Areas:

Examples of interest areas that ORIP may consider include:

  • Support of alterations and renovations (A&R) of research facilities
  • Purchase of instrument(s)/equipment critical for biomedical research
  • Importation costs of a special collection to an ORIP supported repository
Administrative Supplement Contact:

Principal Investigators are encouraged to speak to their eRA assigned Program Official before applying to discuss eligibility, need for the supplement, availability of funds, and application procedures.

General Inquiries:

Division of Comparative Medicine

[email protected]

Small Business
In addition to our Small Business overview, consider the following ORIP-specific information.
Small Business Interest Areas:

ORIP supports research projects to develop technology including, but not limited to, the following: 

  • Create, characterize, or improve models of human disease; and develop new approach methodologies (NAMs) to complement or reduce the use of animal models in research. 
  • Preservation, revival and monitoring of cells, tissue, organs or gametes from model systems. 
  • Validate research models to enhance the rigor and reproducibility of pre-clinical studies. 
  • Devices and technologies required for development and maintenance of conventional and NAM biological model systems, including those for advancing the care, welfare, housing, and management of these models; or sensor and monitoring technologies for the surveillance of models or environmental factors that lead to improved rigor and reproducibility for studies using these models.
Phase IIB & Commercialization Readiness Pilot (CRP):
  • ORIP accepts Phase IIB SBIR projects
Centers Contact:

General Inquiries:

ORIP Small Business

[email protected]

See Also

Office of Research Infrastructure Programs (ORIP)

For technical issues E-mail OER Webmaster