National Human Genome Research Institute (NHGRI)

• Program Directors/Principal Investigators (PDs/PIs) with an active NHGRI grant may request an administrative supplement to support unanticipated costs not included in the most recent competitive or non-competitive application.

• PDs/PIs are strongly encouraged to consult with their NHGRI Program Officer (PO) to confirm eligibility, discuss the scope and justification of the proposed supplement, and obtain technical guidance.

   

• Requests may be submitted at any time during the fiscal year but should be made at least 90 days before the anticipated need and no later than March 15.
• Due to fiscal and system constraints, supplements are not awarded in October or November. 

NHGRI Research Funding

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NHGRI supports conferences and meetings that promote the development and exchange of information focused on genome sciences, genomic medicine, computational genomics and data science, the ethical, legal, and societal implications (ELSI) of genomics research, as well as those that promote the training and mentoring of the next generation of genomic researchers. Applications for conferences and meetings relevant only to a particular disease or organ system should be directed to the appropriate Institute or Center.

NHGRI particularly encourages applications that strengthen the capabilities of U.S. scientists, especially those aimed at significantly enhancing research skills aligned with priorities outlined in the NHGRI Strategic Vision.

Although prior approval is not required, prospective applicants are strongly encouraged to contact NHGRI program staff at least six weeks before the intended submission date.

NHGRI has limited funds available to support conferences and meetings. Proposed budgets must be well justified and appropriately aligned with the scope, scale, and anticipated impact of the meeting.

NHGRI will consider applications requesting support for a series of annual or biannual events for up to 5 years.

NHGRI Research Funding
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NHGRI participates in Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowships (F30, F31, F32) and the Predoctoral to Postdoctoral Transition Award. NHGRI does not support F30 applications for students at institutions with NIH-funded institutional predoctoral dual-degree training programs. Prospective applicants are strongly encouraged to contact NHGRI program staff prior to submitting an application. 

Pre- to Postdoctoral Transition Fellowship (F99/K00)

• NIH F99 recipients planning to transition to the K00 phase should contact their NIH Program Official as soon as postdoctoral plans develop, and no later than six months before the anticipated K00 start date. Recipients should discuss their transition timeline, eligibility, and required materials for activating the K00 phase.
   

Pre- to Postdoctoral Transition Fellowship (F99/K00)

• F99 Predoctoral: Minimum of 1 year and up to 2 years
• K00 Postdoctoral: Up to 3 years
   

Pre- to Postdoctoral Transition Fellowship (F99/K00)

• NHGRI will provide an additional $1,500 in each grant year for F99/K00 recipients to defray travel costs to attend the NHGRI Research Training and Career Development Annual Meeting.
• For the K00 phase, NHGRI will contribute to the K00 salary in each grant year up to $80,000 and will provide up to $20,000 in each grant year towards Research and Development costs for the award recipient, which must be justified and consistent with the stage of development of the candidate and the proportion of time to be spent in research training and/or career development activities.  
   

NHGRI Training Fellowships
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NHGRI supports research education programs that enhance the knowledge and research skills of scientists working in all scientific areas relevant to the NHGRI mission. These programs may include mentored research experiences, mentoring activities, and courses designed to strengthen participants’ research training. Prospective applicants are strongly encouraged to contact NHGRI Program Staff prior to submitting an application. 

NHGRI strongly encourages applications that provide high-quality, hands-on research experiences for undergraduate and post-baccalaureate students. These programs should prepare participants for careers in genomics by engaging them in research aligned with NHGRI priority areas.

NHGRI also encourages applications that provide hands-on research experiences for Master’s-level genetic counselors and students enrolled in Data Science Master’s programs (e.g., statistics, biostatistics, mathematics, computer science). The goal is to attract these trainees to the genomics workforce and to encourage master’s-level data scientists who do not plan to pursue doctoral training to contribute to genomics research.

• Undergraduate
• Predoctoral
• Postdoctoral/Residency
• Early Career
• Established Investigator

NHGRI will support personnel costs of up to 30% of the total direct costs for applications that focus on research experience. Consultant costs, equipment, supplies, travel for key persons, and other program-related expenses may be included in the proposed budget. These expenses must be justified as specifically required by the proposed program and must not duplicate items generally available at the applicant institution.

NHGRI encourages applicants to request up to $1500 of travel allowance to support travel to the NHGRI Research Training and Career Development Annual Meeting.

• NHGRI awards Research Education Cooperative Agreements (UE5)
• NHGRI awards Research Education Grant Projects (R25)

NHGRI Research Funding
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• Significant innovations in genomic methods or technology development. This includes, but is not limited to, advancements in nucleic acid sequencing, synthetic nucleic acid synthesis, functional genomics, single cell genomic analysis, transcriptomics, multi-omics, instrumentation, or molecular kits. 
• Tools and techniques that use genomics to improve patient health, such as approaches to incorporate genomic results into electronic medical records, clinical decision support tools, or genomic directed health care. 
• Strategies to enhance ethical, legal, and social aspects of genomics research or translation of genomics into health care. 
• Bioinformatics software or platforms for genomic, genetic, or sequence data processing or analysis, functional genomics, associations between genomic data and diseases or phenotypes, interpretation of variants, or genomic data integration into clinical decision making. 
• Databases and data management platforms for genomics research and application including platforms for sequence, functional, or phenotypic data or annotation of variants. 
• Development and application of methods for machine learning, pattern detection, or knowledge networks for genomics science or translation into health care. 
• Informatics methods and platforms that adopt data standards, enhance data sharing with privacy, and improve data exchange in genomics science or translation of genomics into health care. 
• Use of cloud and other computing models to improve scale, reproducibility, interoperability, cost-effectiveness, and utility of genomic and clinical data in genomics or translation into health care. 
• Development of curriculum and educational opportunities that increase the genomics knowledge of participants at the undergraduate, postbaccalaureate, graduate, postdoctoral, or professional levels. 

NHGRI Small Business

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