Peer Review Policies & Practices

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"To maintain our edge . . . we've got to protect our rigorous peer review system and ensure that we only fund proposals that promise the biggest bang for taxpayer dollars . . . that's what's going to maintain our standards of scientific excellence for years to come."

Remarks by President Barack Obama on the 150th Anniversary of the National Academy of Sciences, April 29, 2013

What's New in Peer Review

Friday, April 25, 2014

Updated Submission Policy.  The NIH announced an updated policy for application submissions that allows applicants to come in with a new application after an unsuccessful resubmission.  See NOT-OD-14-074 and NOT-OD-14-082, and FAQs on application submission. 

Research Training Programs.  Following recommendations of the Biomedical Research Workforce Task Force, the NIH is implementing changes to the review criteria used to evaluate applications for fellowships, career development awards, and training grants.  See the Guidelines and Fill-able Templates for Reviewers.

Thursday, Feb. 6

Experiments in Peer Review The NIH is undertaking several new experiments that involve the peer review process (See Collins and Tabak, Nature 505: 612-613).


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Information for Reviewers

How to Volunteer.  Consider volunteering to serve in the NIH peer review process.  See Becoming a Peer Reviewer.

Incentives for Reviewers: Continuous Submission.  Certain reviewers may be eligible for Continuous Submission. The continuous submission policy has been changed.

Materials for Reviewers.  Standardized guidelines, instructions, and critique templates that reviewers use are posted at Guidelines for Reviewers.

Protecting NIH Grant Applications.  Reviewers must take every reasonable precaution to safeguard NIH grant applications and related materials, which are considered highly confidential.  See: 

Maintaining Confidentiality.  Each NIH reviewer must certify that s/he has read and will abide by the NIH confidentiality and nondisclosure rules.  See Confidentiality in NIH Peer Review.

Declaring Lobbyist Status.  Each NIH reviewer must certify that s/he is not a federally-registered lobbyist before participating in NIH peer review.  See OFACP Policy of September 2012.

Managing Conflicts of Interest.  Each NIH reviewer must certify that s/he has declared all known conflicts of interest before the review meeting, and after the meeting, that s/he did not participate in the evaluation of an application with which s/he has a conflict of interest.  See:

NOT-OD-13-010 (11/30/2012): Advance Notice: Revised Policy for Managing Conflict of Interest in the Initial Peer Review of NIH Grant and Cooperative Agreement Applications

  • Grants: COI Reviewer Guidance - Fed - (PDF - 328 KB)
  • Grants: COI Reviewer Guidance - Non Fed - (PDF - 330 KB)

Evaluating Human Embryonic Stem Cells.  In assessing overall impact, reviewers evaluate the scientific appropriateness of proposed hESC lines or the justification for using a cell line that is not listed on the NIH Registry for Stem Cells.  See NOT-OD-12-111 (6/11/2012).

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Information for Applicants

Overview of Peer Review.  For a general overview of NIH peer review, visit Peer Review Process, or see Core Values of NIH Peer Review for a more detailed understanding. 

Regulations Governing NIH Peer Review. View 42 CFR 52h: Scientific Peer Review of Research Grant Applications and Research and Development Contract Projects:

Appeals of NIH Initial Peer Review.  The NIH policy and procedure for handling appeals of the outcome of initial peer review are explained in:

  • NOT-OD-11-064 (04/15/2011): Appeals of Initial Peer Review
  • NOT-OD-11-101 (7/29/2011): Resubmission of Applications with Pending Appeals of NIH Initial Peer Review

Post-submission Materials.The NIH accepts certain materials and videos as application materials after the application has been submitted but before peer review.  See:

  • NOT-OD-13-030 (1/29/2013): Reminders and Updates: NIH Policy on Post-Submission Application Materials
  • NOT-OD-12-141 (9/27/2012): Interim Guidance for Videos Submitted as NIH Application Materials
  • NOT-OD-12-111 (6/11/2012): Notice of Impending Change in Peer Review Criteria and Submission Requirements for NIH Applications Involving Human Embryonic Stem Cells

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Advisory Councils or Boards

NIH Advisory Councils and Boards perform the second level of NIH peer review, and make recommendations to the Institutes and Centers.

Assessing Objectivity.  Professional situations may cause an objective observer to question the integrity of Council review.  See Guidance for Members of NIH Advisory Councils and Boards (PDF - 389 KB).

Special Council Review.  Notice of NIH Special Council Review of Research Applications from PDs/PIs with More than $1.0 Million Direct Costs in Annual NIH Support.  See NOT-OD-12-140 (8/20/2012).

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