AIDS INTERNATIONAL TRAINING AND RESEARCH PROGRAM

Release Date:  December 14, 1999

RFA:  TW-00-003

Fogarty International Center

Letter of Intent Receipt Date:  January 21, 2000

Application Receipt Date:  February 25, 2000

PURPOSE

The Fogarty International Center (FIC), National Institutes of Health 
(NIH), invites applications from non-profit private or public U.S. 
institutions with interest in working with foreign colleagues to build 
global HIV/AIDS and related tuberculosis (TB) research capacity to 
prevent HIV transmission and TB.  This RFA describes the process by 
which new and competing renewal applicants can apply for funding under 
the AIDS International Training and Research Program (AITRP) and also 
describes opportunities listed on the AITRP website for existing 
programs to apply for competing supplements for geographic and 
programmatic expansions.  AITRP supports HIV/AIDS and related TB 
international training and research for foreign health scientists, 
clinicians, and allied health workers from developing countries and 
emerging democracies.  Countries in Central and Eastern Europe and the 
former Soviet Union are eligible to participate, as are countries in 
Africa, the Americas, Asia and the Pacific Region.

Under AITRP, scientists are trained to address the global HIV/AIDS and 
related TB epidemic through research.  AITRP helps to:  (1) establish 
critical biomedical and behavioral science expertise in developing 
countries affected by HIV/AIDS and TB; (2) facilitate new prevention 
research efforts which supplement or complement NIH and other U.S. AIDS 
and TB research; (3) establish long-term cooperative relationships 
between U.S. and foreign research groups; and (4) support cooperation 
between U.S. academic research centers and foreign scientists.  
Applicants are strongly encouraged to relate training to ongoing 
prevention research efforts in developing countries and emerging 
democracies supported by NIH and other organizations.

In October 1996, the FIC convened a panel of scientists to conduct a 
comprehensive review of AITRP (final report at FIC AITRP website 
(http://www.nih.gov/fic/opportunities/aitrp/aitrp.html).  Based upon 
that review, the FIC adopted the following mission and goal statement 
for the program:

“The mission of the AITRP is to train international health professionals 
in research on prevention of HIV infection.” 

The interpretation of this mission statement is broad and encompasses 
not only prevention of HIV transmission and infection, but also 
prevention of progression of HIV infection to AIDS.

This RFA reflects most recommendations of the panel and also supports 
the NIH efforts to develop a coordinated and comprehensive Prevention 
Science Agenda that includes and combines biomedical, behavioral, and 
social interventions.  
It refocuses AITRP from an emphasis on epidemiology to prevention 
research involving multiple biomedical and behavioral science 
disciplines.  Applicants are strongly encouraged to propose 
multidisciplinary training in one or more areas in each of these two 
broad fields, in addition to a core component of data management and 
analysis.  Programs should ensure that trainees receive a range of 
experiences in biomedical and behavioral activities such that taken 
together, they would likely lead to a sustainable research and public 
health capacity to prevent HIV transmission.

The AITRP website contains additional information of interest to 
applicants:

o  Opportunities for existing AITRP programs to propose competing 
supplements under expanded activities;

o  Future areas of program interest, subject to availability of funds; 
and

o  Answers to frequently asked questions.

The FY 2001 NIH Plan for HIV-Related Research, available at 
http://www.nih.gov/od/oar/updates/updates.htm, describes overall NIH HIV 
research priorities.  Applicants are encouraged to review and consider 
these documents in preparing their applications.

Research and public health capacity is built in large part through 
individuals participating in the research process and, therefore, AITRP 
programs are strongly encouraged to link training with NIH-supported and 
other research programs.  Training and research should mutually 
reinforce each other.  AITRP is not expected to necessarily be active in 
all countries with significant HIV or TB incidence or prevalence.  
Rather, the demonstrated capacity and/or potential to achieve sustained 
research and training efforts within a country will be the priority.  
The emphasis in AITRP will be depth, not breadth; programs that focus on 
a relatively few sites or countries would likely have a greater impact 
than those that dilute their resources across many countries.

Given the interrelationship between the occurrence of HIV and TB and the 
high mortality rate in persons infected by both HIV and TB, including 
multiple drug resistant TB, up to 50 percent of requested funds for new 
awards can be for tuberculosis provided that the proposed program is 
linked to a current or expected future epidemic of HIV/AIDS.  An 
applicant whose primary capabilities are in the area of TB can 
collaborate with another FIC AITRP working in the same country to 
provide the necessary expertise related to HIV/AIDS.  Applicants are 
strongly encouraged to develop TB training and capacity building in 
collaboration with or in support of projects funded by the National 
Institute of Allergy and Infectious Diseases (NIAID), Centers for 
Disease Control and Prevention (CDC), United States Agency for 
International Development (USAID), and the International Union Against 
Tuberculosis and Lung Disease (IUATLD).

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health 
promotion and disease prevention objectives of "Healthy People 2000," a 
PHS-led national activity for setting priority areas.  This Request for 
Applications, AIDS International Training and Research Program (AITRP), 
is related to the priority area of HIV infection. Potential applicants 
may obtain a copy of "Healthy People 2000" at 
http://odphp.osophs.dhhs.gov/pubs/hp2000.

ELIGIBILITY REQUIREMENTS

The grantee institution must be a U.S. nonprofit private or public 
institution capable of meeting the objectives in this RFA.

Only one D43 application will be allowed under this program from each 
U.S. institution.  Institutions that currently hold an award are not 
eligible to submit a second application.  Institutions currently awarded 
an NIH Centers for AIDS Research (CFAR) program but which do not 
currently hold an AITRP award are encouraged to apply.  Applicants are 
also encouraged to collaborate with CFAR programs at other institutions 
and thereby take advantages of the CFAR expertise in the basic and the 
clinical sciences.  Collaboration with CFAR programs is expected to be 
on a cost sharing basis.  For example, in one joint program, AITRP could 
support training of foreign scientists in the United States and in their 
home country and the CFAR could support other costs in the United States 
and support of U.S. scientists at the foreign institution, including 
support for U.S. postdoctoral scientists to receive international 
research career development opportunities.  Within allowable limits, and 
with some cost sharing, research and training collaborations can include 
other industrialized nations in addition to the United States when the 
purpose of that collaboration is to facilitate and/or support activities 
in a common developing country or emerging democracy.

MECHANISM OF SUPPORT

Grants will be made as D43 awards for a total project period of five 
years.  Supplements to existing AITRP grants are limited to the time 
remaining on the existing award.  Continued support during this period 
depends on satisfactory performance as judged by annual progress 
reports; site visits and meetings of program directors; indicators such 
as career progress of trainees (e.g., positions occupied, first author 
publications, presentations, research undertaken and research awards 
received); and impact on developing country capacity for research and 
prevention.

FUNDS AVAILABLE  (New Starts and Competing Renewals)

The FIC intends to commit approximately $2,500,000 (total costs), 
availability of funds permitting, to fund an estimated 6-7 new starts or 
competing renewal awards (including recompeting TB supplements linked to 
competing renewals), depending upon the quality of recommended 
applications.  The total (direct and Facilities and Administrative 
[F&A]) cost per grant for the first year of recompeting programs must 
not exceed $500,000 (and $625,000 including a recompeting TB 
supplement).  First year total costs for new programs must not exceed 
$300,000.

FUNDS AVAILABLE  (Competing Supplements)

Existing programs (not including competing renewals) may request funds 
for competing supplements for expanded activities as described in more 
detail at the AITRP website.  Approximately $1,250,000 is designated for 
this purpose, availability of funds permitting, to support an estimated 
20 competing supplements.  Competing supplement requests in aggregate 
cannot exceed $300,000 (total costs).  Although new and competing 
renewal applicants are not permitted to apply for supplemental funds, 
they are encouraged to address the types of activities described under 
"Expanded Activities" as part of their proposals.

RESEARCH OBJECTIVES

The primary goal of this program is to build research capacity.  This 
program is intended to complement ongoing HIV/AIDS and TB research 
efforts of the NIH and, to the extent possible, of other government, 
non-government and international organizations.  A strong research 
infrastructure results in a good training experience.  Programs are thus 
encouraged to develop human resources in those developing and other 
participating countries that currently are or are likely to be sites of 
HIV/AIDS-related research on HIV and/or TB vaccines, anti-HIV and TB 
drugs, and other HIV and TB interventions.

Training Plan

Emphasis should be given to U.S.-based, long-term (usually a minimum of 
two years) training either leading to an advanced degree or to provide 
postdoctoral training.  Long-term training could include degrees in any 
relevant HIV prevention or TB research field.

This RFA will allow short-term training targeted toward specific needs 
such as learning laboratory techniques required to conduct a research 
study or designing behavioral interventions and initial activities to 
establish relationships in countries where none currently exist.

Types of Training

1.  Training in biomedical and behavioral HIV/AIDS-related prevention 
and related TB research disciplines as well as data management and 
analysis in support of that research which may lead to a M.S. or Ph.D. 
degree for individuals with previous research experience. Duration of 
training is estimated from about two to four years.  Academic courses 
will be taken in the United States.  Research could be conducted in the 
United States, but is encouraged to take place in the trainees’ home 
country.

2.  Training (generally two years in duration) in biomedical and 
behavioral HIV/AIDS-related prevention and related TB research 
disciplines, which may lead to a M.S. degree for individuals without 
prior research experience.  Academic courses will be taken in the United 
States; research would ordinarily be conducted in the trainees' home 
country.

3.  Postdoctoral research experiences (generally two years in duration) 
for foreign health scientists (in the United States) and for U.S. health 
scientists overseas.

4.   Training (approximately three to six months in duration) conducted 
in the United States in laboratory procedures and research techniques in 
support of specific HIV/AIDS prevention and related TB research (for 
example, development of pilot biomedical and behavioral studies); for 
individuals with M.S. and Ph.D. degrees.

5.  In-country, practical and applied short-term training (up to three 
weeks) in support of HIV/AIDS prevention and related TB research for 
professionals, technicians and allied health professionals, including 
training to support local participation in institutional review boards 
(research ethics committees), data and safety monitoring boards and 
community advisory boards.

6.  Advanced research training (approximately one to two years in 
duration) for current and/or former trainees, including re-entry grants 
for in-country prevention research projects such as interventions to 
prevent the further spread of HIV/AIDS and to prevent and treat TB.

7.  Support to enable U.S. faculty to be involved in advanced research 
training activities conducted in-country.

8.  Support to enable new and minority U.S. health science students 
(including medical students and residents) to receive overseas health 
research experiences (generally of three to twelve months duration).

Trainees

Trainees shall be individuals involved in or expected to be involved in 
HIV/AIDS prevention and related TB research activities upon completion 
of training in their home country.  The following categories of 
individuals are eligible for training:

1.  Foreign health professionals (M.D., D.D.S./D.M.D., Ph.D., or 
equivalent);

2.  Foreign professionals with a bachelors or masters degree in a basic 
or health science;

3.  Medical technicians and health care workers; 

4.  Allied health professionals such as behavioral scientists, nurses, 
nurse midwives and social workers;

5.  Current or former AITRP trainees involved in advanced research 
training in their home countries; and 

6.  U.S. health science students, medical residents and postdoctoral 
researchers (participating in collaborative research and research 
training with foreign colleagues).

Programs are strongly encouraged to give special emphasis in selecting 
foreign trainees to include women and to ensure adequate representation 
of women and minorities in selecting U.S. trainees under this program.

SPECIAL REQUIREMENTS

Applicants are required to include training in responsible conduct of 
research as a part of the program.  An award will not be made unless a 
description of such training is included.

Before any funds can be expended for in-country activities, the grantee 
institution must show evidence of approval for collaborative research 
between the United States and foreign countries and institutions through 
an endorsement from the Minister of Health or other appropriate 
government officials as well as from the collaborating institutions.  
Recompeting programs are expected to update their prior agreements.

Applicants must include a plan describing recruitment and selection 
procedures for trainees, for the peer review of training-related and 
advanced in-country research (re-entry grants) as well as plans for 
continued collaboration with former trainees.  AITRP grant applications 
should clarify and completely specify:  (a) criteria and procedures for 
the selection of trainees as, for example, by a committee composed of 
U.S. and foreign investigators at participating institution(s); and (b) 
a mechanism for internal peer review of applications to support in-
country research projects with budgets generally not exceeding $25,000.

As part of their obligations under this program, awardees are required 
to design and implement a system to fully track and document the long-
term impact of this training program on:  (1) careers of current and 
former trainees including whether or not they returned to their home 
country (and to what position) after completion of training; (2) 
research capacity in the home countries of trainees; (3) contributions 
to future NIH-supported international HIV/AIDS and related TB research 
efforts; and (4) impact on prevention activities in the home countries 
of trainees.  Examples include how training allowed participants to 
assume more responsible positions upon returning home, how training 
resulted in funding of collaborative research projects for which 
trainees were either Principal or co-Principal Investigators, and 
publications in which trainees were first authors and which were 
supported by this program.  This tracking system, to follow former 
trainees at least ten years, should be described in the application.

Programs are strongly encouraged to collaborate with other AITRP and 
non-AITRP programs when working in common countries and/or regions.  
Programs are also encouraged to provide training and research capacity 
building in support of in-country projects funded by NIAID, NICHD, NCI, 
NIDCR, NIDA and NIMH. Collaboration also is strongly encouraged with 
international organizations and NGOs [e.g. Joint United Nations 
Programme on AIDS (UNAIDS), the Pan American Health Organization (PAHO), 
the Rockefeller INCLEN program, and the International Union Against 
Tuberculosis and Lung Disease (IUATLD).

Communication

FIC AITRP programs should endeavor to ensure that research results are 
accessible and to facilitate translation of results into clinical and 
public health practice by:  (a) sponsoring in-country meetings for all 
trainees in a country; and (b) establishing a World Wide Web site for 
dissemination of new information and for less formal exchange of 
information among sites.  In addition, grantees are encouraged to 
develop mechanisms to enhance medical informatics capability including 
enhancing access of their foreign collaborators to current published 
literature.

Protection of Human Subjects and Laboratory Animals

Applicable provisions for the protection of human research subjects and 
laboratory animals in research and training activities must be met in 
both domestic and foreign settings.  Title 45 CFR, Part 46, provides 
guidelines concerning Department of Health and Human Services 
regulations for the protection of human subjects.  The requirements for 
using animals are detailed in the Public Health Service Policy on Humane 
Care and Use of Laboratory Animals.  These are available from the Office 
for Protection from Research Risks (OPRR), National Institutes of 
Health, 6100 Executive Boulevard, MSC 7508, Rockville, Maryland 20852-
7508.  Applicants must be sure to meet the requirements of obtaining 
single project assurances from OPRR for all projects involving human 
subjects at foreign sites unless otherwise covered by a multiple project 
assurance.  Applicants must also be sure to obtain the necessary 
assurances including review at both U.S. and foreign sites for research 
in which they are actively engaged by virtue of consultancy (for 
example, resulting in co-authorship) or for research conducted on 
biological samples obtained from scientific colleagues in collaborating 
countries, if the samples are individually identifiable to any of the 
scientists.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups 
and their subpopulations must be included in all NIH-supported 
biomedical and behavioral research projects involving human subjects, 
unless a clear and compelling rationale and justification is provided 
that inclusion is inappropriate with respect to the health of the 
subjects or the purpose of the research.  This policy results from the 
NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43).

All investigators proposing research involving human subjects should 
read the "NIH Guidelines for Inclusion of Women and Minorities as 
Subjects in Clinical Research," which was published in the Federal 
Register of March 28, 1994 (FR 59 14508-14513), and in the NIH Guide for 
Grants and Contracts, Volume 23, Number 11, March 18, 1994 available on 
the web at: http://grants.nih.gov/grants/guide/notice-files/not94-100.html.

INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN 
SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age 
of 21) must be included in all human subjects research conducted or 
supported by the NIH, unless there are scientific and ethical reasons 
not to include them.  This policy applies to all initial (Type 1) 
applications submitted for receipt dates after October 1, 1998.

All investigators proposing research involving human subjects should 
read the "NIH Policy and Guidelines" on the Inclusion of Children as 
Participants in Research Involving Human Subjects that was published in 
the NIH Guide for Grants and Contracts, March 6, 1998, and is available 
at the following URL address: 
http://grants.nih.gov/grants/guide/notice-files/not98-024.html.

Investigators also may obtain copies of these policies from the program 
staff listed under INQUIRIES.

LETTER OF INTENT

Prospective applicants for new, competing renewal or supplemental 
funding are asked to submit, by January 21, 2000, a letter of intent 
that includes a descriptive title of the proposed training and research 
programs; the name, address, and telephone number of the Principal 
Investigator; identities of other key personnel and participating 
institutions in collaborating countries; and the number and title of the 
RFA to which the application may be submitted.  Although a letter of 
intent is not required, is not binding, and does not enter into the 
review of a subsequent application, this information allows NIH staff to 
estimate potential review workload and avoid conflict of interest in the 
review.  The Letter of Intent should be submitted to Dr. Kenneth 
Bridbord listed at the address below under INQUIRIES.

APPLICATION PROCEDURES

Applications are to be submitted on the standard research grant 
application form PHS 398 (rev. 4/98), using the instructions and forms 
for Institutional National Research Service Awards.   Application kits 
are available at most institutional offices of sponsored research and 
may be obtained from the Division of Extramural Outreach and 
Information, National Institutes of Health, 6701 Rockledge Drive, MSC 
7910, Bethesda, MD 20892-7910, telephone (301) 435-0714, email:  
grantsinfo@nih.gov

For purposes of identification and processing, item two on the face page 
of the application must be marked "YES" and the RFA number "TW-00-003" 
and words "AIDS International Training and Research Program” must be 
entered on the face page.

The RFA label available in the PHS 398 (rev. 4/98) application form must 
be affixed to the bottom of the face page of the application.  The RFA 
number "TW-00-003" should be added to the label.  Failure to use this 
label could result in delayed processing of the application such that it 
may not reach the review committee in time for review.  
The sample RFA label is available at: 
http://grants.nih.gov/grants/funding/phs398/label-bk.pdf has been 
modified to allow for this change.  Please note this is in pdf format.

Submit a signed, typewritten original of the application, including the 
checklist, and three signed photocopies, in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

At the time of submission, two additional copies of the application and 
five copies of any appendices must be sent to Dr. Hortencia Hornbeak 
listed in Inquires below.

Applications must be received (not postmarked) by February 25, 2000.  If 
an application is received after that date, it will be returned to the 
applicant without review.

The Center for Scientific Review (CSR) will not accept any application 
that is essentially the same as one currently pending initial review, 
unless the applicant withdraws the pending application.  The CSR will 
not accept any application that is essentially the same as one already 
reviewed.  This does not preclude submission of substantial revisions of 
applications already reviewed, but such applications must include an 
introduction addressing the previous critique.

REVIEW CONSIDERATIONS

Upon receipt, applications will be reviewed by CSR for completeness and 
by FIC and NIAID for responsiveness.  Incomplete applications will be 
returned to the applicant without further consideration.  If the 
application is not responsive to the RFA, the application will be 
returned without review.  Applications that are complete and responsive 
to the RFA will be evaluated for scientific and technical merit by a 
peer review group, convened by NIAID, in accordance with the review 
criteria stated below.

As part of the initial merit review, a process will be used by the 
initial review group in which applications receive a written critique 
and undergo a process in which only those applications deemed to have 
the highest scientific merit, generally the top half of the applications 
under review, will be discussed, assigned a priority score, and receive 
a second level review by the FIC Advisory Board.

Review Criteria

The following criteria apply to new and competing renewal applications.  
Criteria for the review of competing supplements are described in the 
AITRP website under Expanded Activities.  Factors to be considered in 
the scientific evaluation of each application include:

In general, the success of the programs to date (for competing renewals) 
and/or the likelihood that the applicant institution can meet and 
sustain the goals and objectives stated in this RFA and specifically 
considering the following:

(1) Significance

o  The demonstrated capacity to achieve the expected public health and 
scientific contributions of the proposed activity;

o  The demonstrated capacity and/or potential to achieve sustained 
research and training efforts within a country;

o  Adequacy of the academic program; and

o  Demonstrated previous success in training AIDS and TB-related 
scientists and in maintaining collaboration with former trainees 
including assisting former trainees in obtaining support for their 
research upon return to their home countries.

(2) Approach

o  Adequate balance in the proposed training program to provide breadth 
of training opportunities in the fields of 1) biomedical and clinical 
prevention research; 2) social and behavioral research; and 3) data 
management and analysis;

o  Adequacy of the mix of long- and short-term training to achieve the 
goals of this RFA;

o  Adequacy of opportunities for trainees to become involved in research 
projects conducted in their home countries;

o  Adequacy of proposed procedures and criteria for 1) recruitment, 
review and selection of trainees and 2) peer review of research 
projects;

o  Demonstrated capacity and/or potential to collaborate with other 
institutions and to coordinate program activities with related efforts 
of other FIC and NIH programs, other federal agencies (e.g., CDC and 
USAID), international organizations (e.g., UNAIDS and PAHO), and NGOs 
[e.g., the International Union Against Tuberculosis and Lung Disease 
(IUATLD), and the Rockefeller INCLEN program];

o  Demonstrated capacity and/or potential to provide overseas research 
experience for U.S. health science students and medical residents, 
including new and minority U.S. health scientists from AITRP and non-
AITRP institutions, such as HBCUs, Minority International Research and 
Training Programs as well as plans to include an adequate representation 
of women among foreign and U.S. trainees; and 

o  Adequacy of the proposed systems for documenting the long-term impact 
of the program on research and public health capacity in the home 
countries of trainees including the impact of the program on the careers 
of current and former AITRP trainees.

(3) Innovation

o  Demonstrated overall creativity of the training and research plan; 

o  Adequacy of plans for trainees to become involved in research 
projects conducted in their home countries; and

o  Adequacy and creativity of plans to use modern information technology 
to facilitate access to scientific information, distance learning, data 
management and analysis, as well as coordination and research 
collaboration.

(4) Investigator(s)

o  Adequacy of qualifications of the program director to lead and the 
named faculty to participate in the proposed training and research 
program;

o  Demonstration of previous international collaboration with scientists 
from developing countries and emerging democracies and institutions 
included in the proposed program;

o  Adequacy of the program director’s and faculty’s experience in the 
fields of 1) prevention; 2) biomedical, social and behavioral research; 
and 3) data management and analysis;

o  Adequacy of research support of program director and participating 
faculty; and

o  Demonstration of career accomplishments of former trainees including 
extent of former trainees’ involvement in the proposed program.

(5) Environment

o  Demonstration of continued or of future support for the program from 
governments and institutions and other non-governmental organizations 
from collaborating countries;

o  Demonstrated support for domestic and international AIDS and TB-
related research and training as evidenced by support from the NIH or 
other sources.  Examples include research support by NIAID, NICHD, NCI, 
NIDCR, NIDA and NIMH;

o  Adequacy of resources and training environment in-country as 
evidenced by 1) the quality of teaching and research facilities and 
other resources in-country; 2) the availability of high-quality 
candidates; and 3) past history of success in former trainees' returning 
to their home countries and their continued involvement in the program, 
for example, in advanced in-country research, as research collaborators 
with U.S. scientific colleagues and/or as faculty and mentors for new 
trainees; and

o  Adequacy of training environment in the United States including the 
institutional commitment, the caliber of preceptors, the quality of 
teaching and research facilities and resources.

The initial review group will also examine the adequacy of the process 
for providing for protection of human and animal subjects and the safety 
of the research environment, as well as plans to include training in 
responsible conduct of research and training in the operations of IRBs, 
data and safety monitoring boards and community advisory boards.  IRBs 
in the home countries of trainees will be responsible for determining 
adequacy of inclusion of women, children and minorities in research 
involving human subjects in their countries.

Allowable Costs

o  Details concerning allowable costs are described within the AITRP 
website (http://www.nih.gov/fic/opportunities/aitrp/aitrp.html).

Expanded Activities

o  Areas of interest for expanded activities (both geographic and 
programmatic) are described in detail on the AITRP website 
(http://www.nih.gov/fic/opportunities/aitrp/aitrp.html).

Schedule
Letter of Intent Receipt Date: January 21, 2000
Application Receipt Date: February 25, 2000
Review for Scientific Merit: June, 2000
Review by the FIC Advisory Board: September, 2000
Anticipated Award (Start) Date: September 29, 2000

AWARD CRITERIA

The following will be considered in making funding decisions for new and 
competing renewal applications and supplemental proposals (as 
indicated):

o  quality of the proposed project as determined by peer review;

o  the extent and effectiveness of efforts made by applicants in 
developing multidisciplinary biomedical and behavioral research training 
programs necessary to support prevention research efforts in the home 
countries of trainees;

o  efforts made to collaborate with other AITRP and FIC/NIH programs and 
institutions and with other organizations;

o  the extent to which proposed training programs generally support and 
complement other NIH-funded international HIV research efforts (and 
specific NIH-funded research projects for competing supplements);

o  program balance among critical research training areas of emphasis 
such as, but not limited to, preparation for future prevention and 
related research efforts including trials of HIV vaccines, anti-HIV 
drugs, anti-TB drugs and other interventions (e.g., microbicides, 
behavioral interventions, nutritional supplementation, prevention of 
mother-to-child HIV transmission); 

o  geographic distribution among countries included in applications 
under consideration, including the need for a given program to work in a 
specific country (such as linkage with another NIH-supported research 
project in that country); and

o  For competing supplements:  Overall program priority and relevance 
for those proposals.

The anticipated date of award is September 29, 2000.

INQUIRIES

Prospective applicants are strongly encouraged to discuss their 
applications, including proposed collaborating countries and 
institutions with FIC program staff (see below) before submitting formal 
applications.

All programmatic and scientific inquiries should be directed to:

Kenneth Bridbord, M.D.
Director
Division of International Training and Research
Fogarty International Center
National Institutes of Health
Building 31, Room B2C39
31 Center Dr MSC 2220
Bethesda, MD  20892-2220
Phone:  (301) 496-2516
FAX:  (301) 402-2056
Email:  bridbord@nih.gov

Inquiries related to the review of these applications may be directed 
to:

Hortencia Hornbeak, Ph.D.
Associate Director for Scientific Review and Policy
NIH/NIAID/DEA/SRP
National Institutes of Health
6700-B Rockledge Dr, MSC 7616
Bethesda, MD  20892-7616
Telephone:  (301) 496-2550
FAX:  (301) 402-2638
Email:  hh7g@nih.gov

Inquiries regarding fiscal matters may be addressed to:

Mrs. Silvia Mandes
Grants Management Officer
Division of International Training and Research
Fogarty International Center
National Institutes of Health
Building 31, Room B2C39
31 Center Dr MSC 2220
Bethesda, MD  20892-2220
Telephone:  (301) 496-1653
FAX:  (301) 402-0779
E-mail:  Silvia_Mandes@nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance 
No. 93.154.  Awards are made under authorization of the Public Health 
Service Act, Title IV, Part A (Public Law 78-410, as amended by Public 
Law 99-158, 42 USC 241 and 285) and administered under PHS grants 
policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 79.  
This program is not subject to the intergovernmental review requirements 
of Executive Order 12372 or to Health Systems Agency review.

The Public Health Service strongly encourages all grant and contract 
recipients to provide a smoke-free workplace and promote the non-use of 
all tobacco products. In addition, Public Law 103-227, the Pro-Children 
Act of 1994, prohibits smoking in certain facilities (or, in some cases, 
any portion of a facility) in which regular or routine education, 
library, day care, health care or early childhood development services 
are provided to children.  This is consistent with the PHS mission to 
protect and advance the physical and mental health of the American 
people.


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