NINR CAREER TRANSITION AWARD

Release Date:  March 5, 1998

RFA:  NR-98-001

P.T.

National Institute of Nursing Research

Letter of Intent Receipt Date: May 9, 1998
Application Receipt Date: June 9, 1998

PURPOSE

The National Institute of Nursing Research (NINR) is participating in an NIH
pilot program whose overall goals are to enable outstanding individuals to obtain
a research training experience in the NIH intramural clinical research
laboratories and to facilitate their successful transition to an extramural
environment as independent researchers.  The NINR Career Transition Award will
provide up to three years of support for research training in an NINR or NIH
intramural laboratory followed by two years of support for an independent program
of research in an extramural institution.  It is anticipated that awardees will
subsequently obtain a research project grant (R01) to support the continuation
of their work.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of "Healthy People 2000," a PHS-led national
activity for setting priority areas.  This NINR Career Transition Award is
related to priority area of human resource development.  Potential applicants 
may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-
0  or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of
Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-
512-1800).

ELIGIBILITY REQUIREMENTS

Individuals must have a doctorate or its equivalent, and must have demonstrated
the potential for a highly productive research career during doctoral training
and during the immediate postdoctoral period (up to three years of prior
postdoctoral study).  During the intramural phase of the award, the candidate is
expected to spend his/her full time on research.  During the extramural phase,
the candidate must spend a minimum of 75 percent of full-time professional effort
conducting research and engaging in research career development activities for
the two years of the award.

Minorities and women are encouraged to apply.  Candidates must be U.S. citizens
or noncitizen nationals, or must have been lawfully admitted for permanent
residence and possess an Alien Registration Card (I-151 or I-552) or some other
verification of legal admission as a permanent U.S. resident at the time of the
award.  Non-citizen nationals, although not U.S. citizens, owe permanent
allegiance to the U.S.  They are usually born in lands that are not states, but
are under U.S. sovereignty, jurisdiction, or administration.  Individuals on
temporary or student visas are not eligible.

Candidates may have completed up to the first three years of postdoctoral
training at NINR or elsewhere to be eligible for the intramural support phase. 
To progress to the extramural support phase, the candidate must have a formal
tenure-track (or equivalent) offer from an extramural institution.

Current principal investigators on PHS research grants are not eligible.

MECHANISM OF SUPPORT

Awards in response to this RFA will use the NIH Career Transition Award (K22)
mechanism.  Planning, direction, and execution of the candidate's individual
research program will be the responsibility of the candidate and his/her mentor. 
The total period of support is up to five years (up to three years intramural,
plus no more than two years extramural).  There is no grant award associated with
the intramural phase.  Awards are not renewable.  Total cost for the intramural
phase is based on the candidate's experience, not to exceed $125,000; those for
the extramural phase cannot exceed $125,000 plus fringe benefits per year in
direct costs.  The final two years of the scholar's research program will be
supported by the extramural institution to which the scholar is recruited and
will be funded through an extramural, non-competing, NIH Career Transition Award
(K22) mechanism.

FUNDS AVAILABLE

NINR anticipates funding up to three awards in FY 1998.The funding level will be
dependent upon the number of outstanding applications received and funds
available.  The number of scholars who can be supported is based upon the
availability of resources and space in sponsoring intramural laboratories. The
earliest feasible start date for the initial awards will be October 1998.

RESEARCH OBJECTIVES

The NINR intramural research environment provides a unique opportunity for the
training of promising new scientists who will subsequently enter the extramural
biomedical research community and have the potential to become leaders in their
fields of investigation.  The goal of the NINR Career Transition Award program
is to provide highly qualified young investigators with an opportunity to receive
research training experience in the NINR Division of Intramural Research and to
provide them with bridge funding to facilitate the transition of their program
of research to extramural institutions.

The NINR Career Transition Award will consist of two phases:  an intramural phase
and an extramural phase.  The total period of combined intramural support at NINR
and at the extramural institution will be up to five years.  Initially, up to
three years of the research training program will be provided in the Intramural
Support Phase in which the salary of the scholar will be commensurate with
his/her level of experience.  The final two years of the program, the Extramural
Support Phase, will provide salary and funds for supplies, equipment and
technical support thorough the NIH Career Transition Award (K22).  Transition
from the intramural phase of support to the extramural phase is not automatic. 
Approval of the transition will be based in the success of the scholar's research
program as determined by a formal NINR scientific progress review, which will
take place no later than the end of the second or third year of the Intramural
Support Phase, and the evaluation of a research plan to be carried out at the
extramural institution.  Scholars approved to proceed with the second phase of
support will receive notification of approval in writing from the NINR.  The
extramural institution must demonstrate a commitment to the candidate by
providing protected research time and space needed to perform the proposed
research.  Matching funds from the institution for the equipment and supplies
(and if necessary, salary) are encouraged.  Once an application has been received
from the extramural institution on behalf of the candidate, the NINR will process
the Career Transition Award.

INTRAMURAL RESEARCH IN THE NINR

The intramural research program is undergoing rapid expansion.  It currently
consists of one laboratory located on the Bethesda campus.  The focus of the
Wound Healing Laboratory at NINR is to discover the pathophysiological mechanisms
underlying delayed wound healing in chronic wounds such as leg ulcers and
pressure sores. The laboratory collects material from human wounds and in
combination with a variety of in vitro laboratory methods and model systems
examines factors or mechanisms that may contribute to delayed wound healing.

A more complete description of the Intramural Research Program may be obtained
from:  http://www.ninr.nih.gov/woundlab.htm or by writing to:

Annette B. Wysocki, Ph.D., RNC
Scientific Director
National Institute of Nursing Research
Building 9, Room 1W125, MSC 0967
Bethesda, MD  20892-0967
FAX:  (301) 435-3435
Email:  annette_wysocki@nih.gov

Other intramural research opportunities are available. Details may be obtained
by contacting Dr. Annette Wysocki. Scientific Director, NINR.

ALLOWABLE COSTS

Intramural Support Phase:

The budget for the Intramural Support Phase includes the scholarĂ¾s salary and
research expenses determined by the Scientific Director. The salary must be
commensurate with the level of training and experience specified in the Federal
pay schedule and will be negotiated with NINR at the time of an award.

Extramural Support Phase:

1.  Salary:  The NIH will provide up to $50,000 in salary plus fringe benefits
for the Career Transition Award recipient.  The total salary requested must be
based on a full-time, 12-month faculty or staff appointment.  It must be
consistent with the established salary structure at the institution and with
salaries actually provided by the institution from its own funds to other faculty
or staff members of equivalent qualifications, rank, and responsibilities in the
department concerned.  There should be no less than 75 percent effort devoted by
the scholar specifically to the proposed program of research.  The institution
may supplement the NIH contribution up to a level that is consistent with the
institution's salary scale; however, supplementation may not be from Federal
funds unless specifically authorized by the Federal program from which such funds
are derived.  In no case may PHS funds be used for salary supplementation. 
Institutional supplementation of salary must not require extra duties or
responsibilities that would interfere with the purpose of the Career Transition
Award.  Under expanded authorities, however, institutions may rebudget funds
within the total costs awarded to cover salaries consistent with the
institution's salary scale.

2.  Research Support:  The NINR will provide up to $75,000 per year for (a)
research expenses, such as supplies, equipment, consultants, patient care costs,
and technical personnel; (b) travel to research meetings or training; and (c)
statistical service, including personnel and computer time.

3.  Ancillary Personnel Support: Salary for secretarial and administrative
assistance, etc., is not allowed.

4.  Indirect costs: Indirect costs will be reimbursed at eight percent of
modified total direct costs, or the actual indirect cost rate, whichever is less.

Special Restrictions:

Acceptance into the NINR Career Transition Award program does not convey any
commitment or intent of the NINR to consider the scholar for a tenure track
position within the NINR.  The NINR Career Transition Award is specifically
intended to help develop scientists who will pursue their career in the
extramural biomedical research community.  However, the NINR Career Transition
Award scholars are not explicitly precluded from applying for available tenure
track positions at the NIH.  If a scholar obtains a NIH position, the NINR
scholarĂ¾s Career Transition Award will be terminated.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and their
subpopulations must be included in all NIH-supported biomedical and behavioral
research projects involving human subjects, unless a clear and compelling
rationale and justification are provided that inclusion is inappropriate with
respect to the health of the subjects or the purpose of the research.  This
policy results from the NIH Revitalization Act of 1993 (Section 492B of Public
Law 103-43).

All investigators proposing research involving human subjects should read the
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical
Research,: which have been published in the Federal Register of March 28, 1994
(FR 59 14508-14513) and the NIH GUIDE FOR GRANTS AND CONTRACTS, Volume 23, Number
11, March 18, 1994.

LETTER OF INTENT

Prospective applicants are asked to submit, by May 9, 1998, a letter of intent
that includes a descriptive title of the proposed program of research, the name,
address, telephone and FAX number, and e-mail address of the applicant, and the
number and title of the RFA in response to which the application may be
submitted.  Although a letter of intent is not required, is not binding, and does
not enter into the review of a subsequent application, it allows NINR staff to
estimate the potential review workload and avoid conflict of interest in the
review.

An e-mail or FAX letter of intent is acceptable.

The letter of intent is to be sent to:

Office of Review
Division of Extramural Activities
National Institute of Nursing Research
45 Center Drive, Room 3AN12 -  MSC  6300
Bethesda, MD  20892-6300
Telephone:  (301) 594-6906
FAX:  (301) 480-8260

APPLICATION PROCEDURES

Individuals interested in applying for the NINR Career Transition Award must
identify a mentor in the NINR Division of Intramural Research prior to submitting
an application for this phase of the award.  Candidates may have undertaken their
first three years of postdoctoral training in an NINR or NIH laboratory and will,
in most cases, retain their original mentor.  Other candidates should consult the
published descriptions of the NINR program and communicate directly with the
mentors whose research compliments their own interests.  The application must
include information regarding the candidate's long-term career plan, a career
development plan, a research plan, and the mentor's statement of support.

Applications are to be submitted on form PHS 398 (rev. 5/95) and will be accepted
on or before the receipt deadline of June 9, 1998.  These forms are available at
most institutional offices of sponsored research and from the Division of
Extramural Outreach and Information Resources, 6701 Rockledge Drive, MSC 7910,
Bethesda, MD 20892 (telephone: 301/435-0714; E-mail: asknih@od.nih.gov).

The application must address the following issues:

Candidate

o Establish the candidate's commitment to a career in biomedical or behavioral
research.

o Establish the candidate's potential to develop into a successful independent
investigator.

o Summarize the candidate's immediate and long-term career objectives, explaining
how the award will contribute to their attainment.

o Letters of recommendation.  Three sealed letters of recommendation addressing
the candidate's potential for a research career must be included as part of the
application.

Research Plan

o Describe the research plan and the use of a basic or clinical approach to a
biomedical or behavioral problem.  The candidate must describe the research plan
as outlined in form PHS 398 including sections on the Specific Aims, Background
and Significance, Progress Report/Preliminary Studies, Research Design and
Methods.

Budget

o Do NOT provide any dollar figures in the application.  The final budget will
be negotiated when a selected applicant accepts a position and will be within the
allowable costs specified above.

For candidates who receive approval for transition to extramural support, a
budget will be submitted as part of the form PHS 2590 noncompeting application
as discussed below in Extramural Support Phase.

Career Development Plan

o Describe the career development plan, incorporating consideration of the
candidate's goals and prior experience.  It should describe a systematic plan to
obtain the necessary basic biomedical or behavioral science background and
research experience to launch an independent research career.

o The application must include a biographical sketch and information on the
mentor(s) including research qualifications and previous experience as a research
supervisor.  The application must also include information that describes the
nature and extent of supervision that will occur during the proposed award
period.  A letter of support from the mentor must be included in the application
delineating the match with the applicant's research and development plan and
willingness to provide the necessary assistance.

The initial application for the NINR Career Transition Award program will NOT be
processed through your current institution; therefore, follow the supplemental
guidelines below for the face page:

To identify the application as a response to this RFA, check "YES" on item 2a of
page 1 of the application and enter "RFA-NR-98-001, NINR Career Transition
Award."

The applicant must provide her/his signature in item 15; signature is not
required for item 16.

Leave items 9-14 and 16 on the face page blank.

Enter in item 6 (Dates of Proposed Period of Support) the combined 5 years of
support needed to complete the intramural and the extramural support phases of
the NINR Career Transition Award Program.

Utilize the "Research Career Award" Table of Contents page, but re-label the
page, "Career Transition Award."  This page is included in the Form 398 packet
and will facilitate organizing the research and career development components of
the application.  Add a "Career Development Plan" under "Section II: Specialized
Information."

Submit a signed, typewritten original of the application, including the
Checklist, and three signed photocopies, in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040  MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

Applications must be received by June 9, 1998.  If an application is received
after that date, it will be returned to the applicant without review.  The Center
or Scientific Review (CSR) will not accept any application in response to the RFA
that is essentially the same as one currently pending initial review, unless the
applicant withdraws the pending application.  The CSR will not accept any
application that is essentially the same as one already reviewed.

At the time of submission, two additional copies of the application must be sent
to:

Office of Review
Division of Extramural Activities
National Institute of Nursing Research
Building 45, Room 3AN-12
Bethesda, MD  20892-6300

REVIEW CONSIDERATIONS

Upon receipt, applications will be reviewed for completeness by the Center for
Scientific Review and responsiveness to the RFA by NINR staff. Applications that
are complete and responsive to the program announcement will be evaluated for
scientific and technical merit by an appropriate initial peer review group,
convened by the NINR Division of Extramural Activities. As part of the initial
merit review, all applications will receive a written critique and may undergo
a process in which only those applications deemed to have the highest scientific
merit will be discussed and assigned a priority score.  All applications will
receive a second level of review by the National Advisory Council for Nursing
Research.

Review Criteria

The peer review criteria for applications submitted in response to this RFA are:

Candidate

o Commitment to an independent research career;

o Potential to develop as an outstanding scientist who will make significant
contributions to the field;

o Quality and breadth of prior scientific training and experience including,
where appropriate, the record of previous research support and publications.

Research Plan

All candidates for this award will have had previous research experience.  A
sound research plan that is consistent with the candidate's level of research
development must be provided.

o Usefulness of the research plan as a vehicle for enhancing existing research
skills as described in the career development plan;

o Scientific and technical merit of the research question, design and
methodology, judged in the context of the candidate's previous training and
experience;

o Adequacy of plans to include both genders and minorities and their subgroups
as appropriate for the scientific goals of the research.  Plans for the
recruitment and retention of subjects will also be evaluated.

Career Development Plan

o Appropriateness of the career development plan, considering the candidate's
goals and prior experience;

Mentor

o Adequacy of the nature and extent of supervision that will occur during the
proposed award period;

o Appropriateness of the mentor's research interests and qualifications to the
career development needs of the candidate.

SELECTION PROCEDURES

Following peer review, the written evaluations and priority score assigned to the
application by the initial review group will be sent to the candidate.

Intramural Support Phase

The applications will be considered by a NINR Selection Committee (NSC)
consisting of Senior Scientists from the NINR Intramural Program and selected
senior intramural and extramural scientists with specific content expertise. 
Based on priority score ranking and programmatic needs, this committee will
identify the pool of highly meritorious candidates to be invited for an
interview.  Following interviews, a ranking and matching process considering both
the candidates and the sponsoring intramural laboratories/branches will be used
to determine the final awards.

Extramural Support Phase

The NINR will conduct a formal scientific progress review no later than the end
of the second year of the Intramural Support Phase to determine whether or not
the scholar will be recommended for the extramural phase of support.  At the same
time, the scholar will prepare a research plan for the extramural phase of the
award.  This review will be conducted by an NINR Progress Review Committee
composed of members of NSC, and other intramural and extramural scientists as
appropriate.  The results of the review will constitute a final evaluation of the
intramural phase and be presented in writing to the scholar.  Approval will
result in eligibility for the extramural phase of funding of the Career
Transition Award, and up to a third additional year of intramural support to
facilitate the transition to an extramural laboratory.

Approval of the transition to the extramural support phase could be made at any
time prior to the end of  second year of the intramural support phase.  Whenever
review and approval occur, the scholar remains eligible for up to one additional
year of intramural support. However, any remaining unused portion of the
intramural support phase will not be carried over into the two-year extramural
support phase.

The scholar must be accepted by an extramural institution which will request a
change in institution by submitting a form PHS 2590 noncompeting application
which must include an updated research proposal and budget.  The application
submitted by the scholar and the extramural institution for activation of the 
extramural phase of the program will be evaluated for completeness and
responsiveness to the program by the extramural program administrator and Grants
Management Office.

AWARD CRITERIA

Applications will compete for available positions/funds with all other scored
applications submitted in response to this RFA. The following will be considered
in making award decision: qualifications and potential of the applicant and
quality of the proposed research project as determined by peer review;
programmatic priorities; and availability of funds. Program recommendations will
be forwarded to the NACNR as informational items.

EVALUATION OF SCIENTIFIC PROGRESS

Intramural Support Phase

Each scholar's research progress will be evaluated on an annual basis like all
other independent intramural scientific research programs.  For this purpose, the
scholar will prepare on an annual basis a progress report, which will be
evaluated by the corresponding laboratory/branch chief and the NINR Scientific
Director.  Additionally, the NINR will conduct a formal scientific progress
review no later than the end of the second year (See section on Selection
Process, Extramural Support Phase).

Extramural Support Phase

The scholar will be required to submit a form PHS 2590 non-competing continuation
application for the final year of extramural support.  The application should
provide a description of the research and career progress of the awardee,
including: 1) publications in press or submitted; 2) current investigator-
initiated research grant support, and 3) all applications submitted for
investigators-initiated research grant support.  After the completion of this
award, periodic updates on various aspects of employment history, publications,
support from research grants or contracts, honors and awards, professional
activities, and other information helpful in evaluating the impact of the program
may be solicited from the scholar.

INQUIRIES

Written and telephone inquiries concerning this RFA are encouraged, especially
during the planning phase of the application.  The opportunity to clarify any
issues or address questions from potential applicants is welcome.

Address inquires to:

Director, Division of Extramural Activities
National Institute of Nursing Research
Building 45, Room 3AN12 - MSC 6300
Bethesda, MD  20892-6300
Telephone:  (301) 594-6906
FAX:  (301) 480-8260

AUTHORITY AND REGULATIONS

The NINR Career Transition Award is made under the authority of Title III,
Section 301 of the Public Health Service (PHS) Act as amended (Public Law 78-410,
as amended, 42 USC 241).  The Code of Federal Regulations, Title 42 Part 52, and
Title 45 Part 74, are applicable to this program.  This program is described in
the Catalog of Federal Domestic Assistance No. 93.361, Nursing Research.  This
program is not subject to the intergovernmental review requirements of Executive
Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a smoke-
free workplace and promote the non-use of all tobacco products.  In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain
facilities (or in some cases any portion of a facility) in which regular or
routing education, library, day care, health care or early childhood development
services are provided to children.  This is consistent with the PHS mission to
protect and advance the physical and mental health of the American people.


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