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Parent and Other Broad Announcements for Investigator-Initiated Grant Applications
Applicants can use these notices of funding opportunities (NOFOs) to submit investigator-initiated applications on a wide range of topics. These opportunities do not describe specific areas of scientific interest. They simply provide the standard policies, forms, and instructions needed to apply. They often use standard due dates with three application, review, and award cycles each year and are typically reissued upon expiration.
Tips for Submitting Investigator-Initiated Applications
- Explore the missions, interest areas, and funding practices of each of our Institutes, Centers, and Offices (ICOs) on our Grants and Funding ICO Profile pages.
- Not all ICOs participate in all listed parent and broad announcements – check the participating organization section of your NOFO carefully prior to applying.
- Reach out to NIH staff to discuss fit within an ICO’s mission and to obtain advice on funding opportunity options.
On this page:
- Administrative Supplements
- Conferences and Meetings
- Individual Career Development (Ks, except K12)
- Individual Fellowships (Fs)
- Institutional Career Development (K12)
- Institutional Training (Ts)
- International Collaboration (PF5)
- Post-award Administrative Actions
- Research Education (R25)
- Research Projects
Administrative Supplements
Visit our Administrative Supplements page for general information and our Administrative Supplements Funding Considerations and Contacts page for ICO-specific information on administrative supplements.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) | PA-26-001 | NIH, ECHO, FIC, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, OBSSR, OD, ODP, ODS, ORIP, ORWH, RM | 11-26-2025 | 12-01-2028 |
Conferences and Meetings
Visit our Conferences and Meetings page for general information and our Conferences and Meetings Funding Considerations and Contacts page for ICO-specific information on conference and meeting support.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) | PA-25-080 | NIH, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ORIP, ORWH | 10-01-2024 | 09-08-2027 |
Individual Career Development (Ks, except K12)
Visit our Individual Career Development page for general information and our Individual Career Development Funding Considerations and Contacts page for ICO-specific information on individual career development awards.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed) | PA-27-037 | OD, INCLD, NCCIH, NCI, NEI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NICHD, NIDA, NIDCD, NIDCR, NIEHS, NIGMS, NIMH, NINDS, OAR, THRO | 06-16-2026 | 04-09-2029 | |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) | PA-24-176 | NIH, NCCIH, NCI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIMH, NIMHD, NINDS, NINR, NLM, ORIP, ORWH | 04-24-2024 | 05-08-2027 | |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) | PA-24-175 | NIH, NCCIH, NCI, NHGRI, NHLBI, NIA, NIAAA, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIMH, NIMHD, NINDS, NINR, NLM, ORWH | 04-24-2024 | 05-08-2027 | |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Required) | PA-24-178 | NIH, NIA, NIAAA, NIDA, NINDS, ODSS, ORWH | 04-26-2024 | 05-08-2027 | |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed) | PA-24-179 | NIH, NIA, NIAAA, NIDA, NIDCR, NINDS, ODSS, ORWH | 04-24-2024 | 05-08-2027 | |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed) | PA-24-182 | NIH, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NLM, ODSS, ORWH | 04-24-2024 | 05-08-2027 | |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required) | PA-24-181 | NIH, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIBIB, NICHD, NIDA, NIDCD, NIEHS, NIMH, NIMHD, NINDS, NLM, ORWH | 04-24-2024 | 05-08-2027 | |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed) | PA-24-185 | NIH, NCCIH, NEI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, ORWH | 04-09-2024 | 05-08-2027 | |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required) | PA-24-184 | NIH, NCCIH, NEI, NHLBI, NIA, NIAAA, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, ORWH | 04-09-2024 | 05-08-2027 | |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed) | PA-24-188 | NIH, NCCIH, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIDA, NIDCD, NIEHS, NIMH, NIMHD, NINR, ODSS, ORWH | 04-25-2024 | 05-08-2027 | |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required) | PA-24-187 | NIH, NCCIH, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIDA, NIDCD, NIEHS, NIMH, NIMHD, NINR, ORWH | 04-25-2024 | 05-08-2027 | |
| Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed) | PA-24-191 | NIH, NCI, NEI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NLM, ORWH | 04-23-2024 | 05-08-2027 | |
| Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required) | PA-24-190 | NIH, NCI, NHLBI, NIA, NIAAA, NIBIB, NICHD, NIDA, NIDCD, NIDDK, NIEHS, NLM, ORWH | 04-23-2024 | 05-08-2027 | |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required) | PA-24-193 | NIH, NCCIH, NHGRI, NHLBI, NIA, NIAAA, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDDK, NIEHS, NIMH, NIMHD, NINDS, NINR, NLM, ORWH | 04-24-2024 | 05-08-2027 | |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) | PA-24-194 | NIH, NCCIH, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ORWH | 04-24-2024 | 05-08-2027 |
Individual Fellowships (Fs)
Visit our Individual Fellowships page for general information and our Individual Fellowships Funding Considerations and Contacts page for ICO-specific information on individual fellowship awards.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) | PA-25-425 | NIH, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR | 06-12-2025 | 05-08-2028 | |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) | PA-25-426 | NIH, NCCIH, NCI, NEI, NHLBI, NIA, NIAAA, NIAID, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIMH, NIMHD, NINR, ODSS | 06-12-2025 | 05-08-2028 | |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) | PA-25-422 | NIH, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM | 06-12-2025 | 05-08-2028 | |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) | PA-25-423 | NIH, NCCIH, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINR, ODSS | 06-12-2025 | 05-08-2028 | |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) | PA-25-424 | NIH, NHLBI, NIAMS, NIDA, NIDCR, NIEHS, NIGMS, ODSS | 06-12-2025 | 05-08-2028 | |
| Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed) | PA-27-037 | OD, INCLD, NCCIH, NCI, NEI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NICHD, NIDA, NIDCD, NIDCR, NIEHS, NIGMS, NIMH, NINDS, OAR, THRO | 06-16-2026 | 04-09-2029 | |
| NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional) | PA-26-002 | OD, INCLD, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ODSS, ORIP, ORWH, RM | 01-20-2026 | 05-08-2029 |
Institutional Career Development (K12)
Visit our Institutional Career Development page for general information and our Institutional Career Development Funding Considerations and Contacts page for ICO-specific information on institutional career development awards.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| Institutional Mentored Career Development Award (Parent K12) (Clinical Trials Not Allowed) | PA-27-030 | OD, INCLD, NEI, NICHD, NIDA, NIDCR, NIDDK, NIEHS, NIGMS, NINDS, OAR, ORWH, THRO | 06-22-2026 | 07-13-2029 |
Institutional Training (Ts)
Visit our Institutional Training page for general information and our Institutional Training Funding Considerations and Contacts page for ICO-specific information on institutional training awards.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) | PA-25-168 | NIH, NBNR, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NINDS, NINR, ORIP, ORWH | 11-15-2024 | 05-05-2028 | |
| Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35) | PA-25-280 | OD, NCCIH, NEI, NHLBI, NIA, NIAAA, NIBIB, NIDCD, NIDDK, NIEHS | 01-02-2025 | 05-08-2028 |
International Collaboration (PF5)
These funding opportunities are specifically designed to support funded international collaborations between a domestic prime organization and foreign organizations NOT-OD-25-104. They should not be used for foreign consultants, purchasing unique equipment or supplies from foreign vendors, foreign collaborations that do not involve NIH funding, or any other foreign component that would not result in a foreign subaward.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional) | PA-26-002 | OD, INCLD, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ODSS, ORIP, ORWH, RM | 01-20-2026 | 05-08-2029 |
Post-award Administrative Actions
Refer to the NIH Grants Policy Statement for Change of Recipient Organization and Change in Recipient Organization Status (e.g., successor-in-interest) information.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| Successor-in-Interest (Type 6 Parent Clinical Trial Optional) | PA-24-253 | NIH, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ODSS, ORIP, RM | 07-11-2024 | 07-18-2027 | |
| Change of Recipient Organization (Type 7 Parent Clinical Trial Optional) | PA-24-254 | NIH, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ODSS, ORIP, RM | 07-11-2024 | 07-13-2027 |
Research Education (R25)
Visit our Research Education page for general information and our Research Education Funding Considerations and Contacts page for ICO-specific information on research education.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| NIH Research Education Program - Courses, Curriculum & Methods (Parent R25 - Clinical Trial Not Allowed) | PA-27-034 | OD, INCLD, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NINDS, NINR, NLM, ODSS, ORWH, THRO | 06-08-2026 | 05-26-2029 | |
| NIH Research Educational Program - Mentoring Activities & Networks (Parent R25/UE5 - Clinical Trial Not Allowed) | PA-27-035 | OD, INCLD, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIDA, NIDCD, NIDCR, NIDDK, NIGMS, NIMH, NINDS, NINR, ODSS, ORWH | 06-08-2026 | 05-06-2029 | |
| NIH Research Education Program - Research Experiences (Parent R25 - Clinical Trial Not Allowed) | PA-27-036 | OD, INCLD, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NINDS, NINR, NLM, ODSS, ORWH, THRO | 06-08-2026 | 05-06-2029 |
Research Projects
Visit our Research Projects page for general information and our Grants and Funding ICO Profile pages for ICO-specific information on research projects.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| NIH Research Project Grant (Parent R01 Clinical Trial Required) | PA-25-305 | NIH, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM | 12-18-2024 | 01-08-2028 | |
| NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) | PA-25-301 | NIH, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ORIP | 12-18-2024 | 01-08-2028 | |
| NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) | PA-25-302 | NIH, NCATS, NCI, NHGRI, NIA, NIAAA, NIAID, NIBIB, NICHD, NIDA, NIEHS, NIMH, NINDS, NLM | 12-18-2024 | 01-08-2028 | |
| NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required) | PA-25-306 | NIH, NCCIH, NCI, NEI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIEHS, NIMH, NIMHD, NINR, NLM | 12-18-2024 | 01-08-2028 | |
| NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) | PA-25-304 | NIH, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIEHS, NIMH, NIMHD, NINDS, NINR, NLM | 12-18-2024 | 01-08-2028 |
Small Business
Visit our Small Business page for general information and our Small Business Funding Considerations and Contacts page for ICO-specific information on small business awards.
| Activity Code(s) |
Title | Announcement Number |
Funding Organization(s) |
Release Date |
Expiration Date |
|---|---|---|---|---|---|
| NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) | PA-27-101 | NIH, NCATS, NCI, NEI, NHLBI, NIA, NIAAA, NIAID, NICHD, NIDDK, NIGMS, NIMH, NIMHD, NINDS, ORIP, ORWH | 05-28-2026 | 04-06-2029 | |
| SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) | PAR-27-098 | OD, NCATS, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, ORIP, ORWH | 05-28-2026 | 04-06-2029 |
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