Notice of Intent to Publish a Request for Applications for Clinical Sequencing Exploratory Research Program (U01)


Notice Number: NOT-HG-12-014

Key Dates

Release Date:  March 29, 2012
Estimated Publication Date of Announcement:  Late Spring 2012 
First Estimated Application Due Date:   July 26, 2012
Earliest Estimated Award Date:  Spring 2013 
Earliest Estimated Start Date:  March 1, 2013 

Issued by

National Human Genome Research Institute (NHGRI)

Purpose

The NHGRI intends to publish a Funding Opportunity Announcement (FOA)  to solicit grant applications for research on exploring, within an active clinical setting, the application of genomic sequence data to the care of patients. This will be a reissue, with modifications, of RFA-HG-10-017 that solicited applications for Clinical Sequencing Exploratory Research (CSER) Program Study Investigators. Applications submitted in response to this FOA will address critical questions about the application of genomic sequencing to clinical care of individual patients, from generation of genomic sequence data, to interpretation and translation of the data for the physician, to communication to the patient, including an examination of the ethical, legal, economic and psychosocial implications of bringing broad genomic data into the clinic.  Further details of the CSER Program are available in RFA-HG-10-017 (http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-10-017.html). 

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published in late Spring, 2012 with an expected receipt date in Summer, 2012.

This FOA will utilize the U01 activity code. Details of the planned Funding Opportunity Announcement (FOA) are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into the clinical application of genome-scale sequence data, including the relevant ethical, legal and psychosocial issues, to begin to consider applying for this new FOA. The goals of the CSER program are to develop and apply methods to integrate sequencing into the clinic, as well as to study relevant ethical, legal, economic and psychosocial issues involved in responsibly applying personal genomic sequence data to medical care.  Applications submitted in response to the CSER Project FOA will include three separate, but highly integrated sub-projects: 1) Clinical Genomics Study; 2) Sequencing, Analysis and Interpretation of Sequencing Data, and 3) Ethical, Legal, Economic and Psychosocial Implications Research, plus a Management Core describing the study management plan.  

APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.

Inquiries

Please direct all inquiries to:

Bradley A. Ozenberger, Ph.D.
Program Director
National Human Genome Research Institute
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892
Telephone: 301-496-7531
Email: bozenberger@mail.nih.gov

Jean E. McEwen, J.D., Ph.D.
Division of Extramural Research
National Human Genome Research Institute
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892-9305
Telephone: 301-402-4997
Email: mcewenj@mail.nih.gov


Weekly TOC for this Announcement
NIH Funding Opportunities and Notices


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