RAPID ACCESS TO INTERVENTION DEVELOPMENT  (RAID) - ADDENDUM

Release Date:  December 13, 1999

NOTICE:  CA-00-004

National Cancer Institute

In the May 11,1998 issue of the NIH Guide for Grants and Contracts, the 
National Cancer Institute (NCI) announced a new initiative: Rapid Access to 
Intervention Development (RAID).  The original Notice can be accessed at the 
following location:  
http://grants.nih.gov/grants/guide/notice-files/not98-070.html.  The purpose 
of the present Notice is to announce a change to the program, effective 
immediately: requests for support should provide evidence of feasibility for 
the preparation of any product proposed for clinical trial.   For more 
information concerning this new requirement, guidelines for submitting 
requests for support, and information on previously supported requests, visit 
the web site, http://dtp.nci.nih.gov/.

RAID will make available to academic investigators, on a competitive basis, 
the preclinical development contract resources of NCI=s Developmental 
Therapeutics Program.  RAID is not a grant program to originating 
investigators.  The goal of RAID is the rapid movement of novel molecules and 
concepts from the laboratory to the clinic for proof-of-principle clinical 
trials.  RAID will assist investigators who submit successful applications by 
providing any (or all) of the preclinical development steps that may be 
obstacles to clinical translation.  These may include, for example, 
production, manufacture of products using current Good Manufacturing Practices 
(cGMP), formulation, and toxicology.  Suitable agents for RAID include small 
molecules, biologics, or vaccines.

This is the third Notice in the NIH Guide for Grants and Contracts regarding 
changes to the RAID program since its inception.  A Notice released on June 
16, 1999 clarified that 1) requests to produce materials ready for use in 
clinical trials must have a letter of commitment from an Institution willing 
to conduct the trial; and, 2) if the receipt dates, February 1 and August 1 of 
each year, fall on a weekend or holiday, the receipt date will be the 
following business day.  A Notice released on December 18,1998 clarified that 
1) academic investigators may have collaborations with small business partners 
and still qualify for RAID funding; and, 2) a maximum of two requests per 
investigator can be submitted per receipt date. 
http://grants.nih.gov/grants/guide/notice-files/not99-110.html.

Requests for RAID resources are to be submitted as described in the web site. 
 Written requests will be evaluated by a specially constituted RAID panel 
consisting of selected NCI staff (non voting) and outside experts from 
academia and industry.  All requests for support must be submitted directly to 
the office listed below under INQUIRIES.

INQUIRIES


Inquiries are encouraged, and the opportunity to clarify issues or questions 
is welcome.  Inquiries may be directed to:

James C. Drake
Coordinator, RAID Program
Special Assistant to the Associate Director
Developmental Therapeutics Program
Division of Cancer Treatment and Diagnosis
National Cancer Institute
6130 Executive Blvd., Room 843
Bethesda, MD 20892
Rockville, MD 20852 (for express/courier service)
Telephone:  (301) 496-8720
FAX:  (301) 402-0831
Email:  drakej@dtpax2.ncifcrf.gov


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